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"With more than 100 genes already known to cause deafness in humans, there are many patients who may eventually benefit from this technology," said Konstantina Stankovic, a professor at Harvard Medical School. Genetic hearing disorders affect some 125 million people worldwide, according to the World Health Organization. An expert not involved in the research welcomed the findings as "very encouraging", but cautioned the technique has yet to be proven safe, and that human trials are likely years away. In the first study, Stankovic and colleagues used a harmless virus to transport -- deep into the mouse ear -- a gene that can fix a specific form of hereditary deafness. Previous attempts had failed, but this time the viral package was delivered to the right address: the so-called outer hair cells that "tune" the inner ear to sound waves. "Outer hair cells amplify sound, allowing inner hair cells to send a stronger signal to the brain," explained Gwenaelle Geleoc, a researcher at the F.M. Kirby Neurobiology Center at Boston Children's Hospital. The technique bestowed hearing and balance "to a level that's never been achieved before," she said in a statement. "Now you can whisper, and the mice can hear you." In the second study, a team led by Geleoc used the same viral courier to treat mice with a mutated gene responsible for Usher syndrome, a rare childhood genetic disease that causes deafness, loss of balance, and in some cases blindness. The virus carried a normal version of the same gene to damaged ear hair cells soon after the mice were born.
We can't plan for that. I can't plan whether there will or won't be cold weather. I can't plan if it'll be warm or cold or rain or whatever. So I think that's the part of our company that sometimes, I think, people forget how nimble we are and how we can with our logistics and distribution network today really manage our inventories well, move inventory around as it's coming into the system, and take advantage of being able to react fast and move sales. But I think I'd like to focus on the things that I think are more challenging and that's the energy markets and then just how we manage weather. And then I'm not going to let any of you forget about deflation. Deflation is a factor. And it's somewhat flat, I guess, to maybe slightly up as we go into this year. But it was a factor of what, I think, about 40 basis points last year. So these are things we deal with.
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